Starting in Jan. 2023, the Feric lab will study how biophysical interactions across multiple scales - molecular, organellar and cellular - contribute to proper cellular organization and how anomalies give rise to age-related diseases. To do so, we take an interdisiplinary approach using biomolecular phase transitions as the working framework. With advanced, super-resolution light microscopy techniques and quantitative analysis, we will probe the organization and function of biomolecules in droplet-like structures called biomolecular condensates, primarily focusing on those found in an organelle highly implicated in aging: the mitochondrion. By identifying the mechanisms by which the cell maintains the organization and activity of its condensates over time, our work will shed light on new approaches to improve human health span and treat age-related diseases.
I am actively looking to recruit at all levels. For PSU graduate students, I am offering virtual rotations Fall 2022. Please contact me with statement of research interests and resume.
I am actively looking to recruit at all levels. For PSU graduate students, I am offering virtual rotations Fall 2022. Please contact me with statement of research interests and resume.
It is remarkable that after a seemingly miraculous feat of morphogenesis a complex metazoan should be unable to perform the much simpler task of merely maintaining what is already formed (Williams 1957).
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